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COMPARISON OF PBPK MODELING SOFTWARE FEATURES AND APPROACHES TO MODELING IMPORTNAT PHYSIOLOGICAL AND BIOCHEMICAL BEHAVIORS
Citation:
DeWoskin, R AND R W. Setzer. COMPARISON OF PBPK MODELING SOFTWARE FEATURES AND APPROACHES TO MODELING IMPORTNAT PHYSIOLOGICAL AND BIOCHEMICAL BEHAVIORS. Presented at SOT, San Francisco, CA, March 25 - 29, 2001.
Description:
Abstract for 40th Annual Meeting of the Society of Toxicology, March 25-29, 2001
COMPARISON OF PBPK MODELING SOFTWARE FEATURES AND APPROACHES TO MODELING IMPORTANT PHYSIOLOGICAL AND BIOCHEMICAL BEHAVIORS. R S DeWoskin and R W Setzer. USEPA/ORD/NHEERL, RTP, NC, USA.
Physiological-based pharmacokinetic (PBPK) modeling software programs continue to evolve and offer a variety of approaches and diverse capability for modeling important physiological and biochemical behaviors. To help researchers evaluate the differences, five software programs were compared for their approach to modeling examples of a number of important physiological and biochemical behaviors including: 1) perfusion limited and diffusion limited kinetics; 2) linear and nonlinear metabolism; 3) growth (and changes in growth rates) in tissue volumes and blood flows; 4) threshold phenomena (and signaling events); 5) positive and negative feedback loops; and 6) time lags. The software programs compared included: 1) ACSL, 2) Matlab, 3) Simulink, 4) Stella, and 5) Berkeley Madonna. The approaches to modeling these behaviors are discussed and samples of the interface, coding, extensibility, and output from each program are presented. A table is also presented that compares the availability for advanced modeling functions such as optimization, sensitivity analysis, Monte Carlo analysis, unit checking and statistical analysis that are inherent in each program or that are available with additional programming or extensions. [This abstract does not necessarily reflect EPA policy.]