You are here:
DETERMINATION OF KOW VALUES FOR A SERIES OF ARYL GLUCURONIDES
Citation:
Kuehl, D W. AND J. Christensen. DETERMINATION OF KOW VALUES FOR A SERIES OF ARYL GLUCURONIDES. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 63:109-116, (1999).
Description:
An important perameter in toxicokinetic modeling is the octanol/water partition coefficient (Kow). This parameter has often been used to predict the accumulation of contaminants from water to fish (Klamer and Beekman 1995); however, few Kow values are available for modeling the behavior of phase ll metabolites within an animal. Therefore, Kow values for the synthesized glucuronides, along with a few commerically available glucuronies, were determined using reversed-phase high performance liquid chromatography (RP-HPLC). The measured values were compared to those predicted by a substituted addative model, CLOGP (Leo and Weinninger 1998). An assessment of this data is presented.