Science Inventory

Impact/Purpose:

Epidemiologic studies have linked poor fetal and infant growth and development to risk of disease and impaired mental function in later life. Interplay between environmental exposures and genetically derived differences in individual metabolism influences fetal growth and development. To assess gene-environment effects, we propose to investigate biomarkers of susceptibility (CYP1A, GSTT1, GSTM1, PON1 polymorphisms), a biomarker of stress (maternal and infant salivary cortisol), two indices of abnormal fetal growth, two sensitive indices of early cognitive development as well as global neurodevelopmental assessments. In addition, timing of exposures in utero windows of susceptibility will be considered. Exposures will be characterized using both PAH-DNA adducts and meticulously constructed historical assessments of particulates (PM) and volatile organic compounds (VOCs), including benzene.

Record Details:

Record Type:PROJECT( ABSTRACT )
Start Date:08/01/2002
Completion Date:07/31/2005