Keywords:
TOXICS, PARTICULATES, PAH, VOC, INFANT GROWTH, INFANT NEURODEVELOPMENT, GENETIC POLYMORPHISMS, DISASTERS, IN UTERO, P450,
Related Organizations:
Role
:OWNER
Organization Name
:MOUNT SINAI SCHOOL OF MEDICINE
Mailing Address
:1 Gustave L Levy Pl
Citation
:New York
State
:NY
Zip Code
:10029
Project Information:
Approach
:We shall undertake this research within a newly established population
of an estimated 300 pregnant women who experienced high exposures in the
immediate aftermath of the World Trade Center (WTC) destruction in September
2001. Growth
will be assessed by weight, height, and head circumference at birth, 9 months,
and at 2 and 3 years of age and neurodevelopment will be assessed at 9 months,
2 and 3 years of age. Biomarkers of maternal exposure to PAH, PAH-related
genes in mothers (CYP1A, GSTT1, GSTM1), a biomarker of maternal stress (cortisol)
are available under a parent grant. Detailed environmental assessments are
being reconstructed for WTC exposures. Funds are now requested to determine
maternal genotypes of PON1, to obtain infant DNA from buccal samples and
infant
genotypes of CYP1A, GSTT1, PON1, to measure infant stress response (cortisol),
to measure infant information processing with the Fagan Infantest and a relatively
newly designed, sensitive test, the Visual Expectation Paradigm (VEXP), and
to evaluate two indices of disproportionality in fetal growth. Using multiple
regression models, we shall examine relationships among exposures (including
stress), timing of exposures (by trimester), at-risk genotypes, and indices
of growth and neurodevelopment.
Cost
:$748,512.00
Research Component
:Children's Health
Approach
:We shall undertake this research within a newly established population
of an estimated 300 pregnant women who experienced high exposures in the
immediate aftermath of the World Trade Center (WTC) destruction in September
2001. Growth
will be assessed by weight, height, and head circumference at birth, 9 months,
and at 2 and 3 years of age and neurodevelopment will be assessed at 9 months,
2 and 3 years of age. Biomarkers of maternal exposure to PAH, PAH-related
genes in mothers (CYP1A, GSTT1, GSTM1), a biomarker of maternal stress (cortisol)
are available under a parent grant. Detailed environmental assessments are
being reconstructed for WTC exposures. Funds are now requested to determine
maternal genotypes of PON1, to obtain infant DNA from buccal samples and
infant
genotypes of CYP1A, GSTT1, PON1, to measure infant stress response (cortisol),
to measure infant information processing with the Fagan Infantest and a relatively
newly designed, sensitive test, the Visual Expectation Paradigm (VEXP), and
to evaluate two indices of disproportionality in fetal growth. Using multiple
regression models, we shall examine relationships among exposures (including
stress), timing of exposures (by trimester), at-risk genotypes, and indices
of growth and neurodevelopment.
Cost
:$748,512.00
Research Component
:Human Health
Approach
:We shall undertake this research within a newly established population
of an estimated 300 pregnant women who experienced high exposures in the
immediate aftermath of the World Trade Center (WTC) destruction in September
2001. Growth
will be assessed by weight, height, and head circumference at birth, 9 months,
and at 2 and 3 years of age and neurodevelopment will be assessed at 9 months,
2 and 3 years of age. Biomarkers of maternal exposure to PAH, PAH-related
genes in mothers (CYP1A, GSTT1, GSTM1), a biomarker of maternal stress (cortisol)
are available under a parent grant. Detailed environmental assessments are
being reconstructed for WTC exposures. Funds are now requested to determine
maternal genotypes of PON1, to obtain infant DNA from buccal samples and
infant
genotypes of CYP1A, GSTT1, PON1, to measure infant stress response (cortisol),
to measure infant information processing with the Fagan Infantest and a relatively
newly designed, sensitive test, the Visual Expectation Paradigm (VEXP), and
to evaluate two indices of disproportionality in fetal growth. Using multiple
regression models, we shall examine relationships among exposures (including
stress), timing of exposures (by trimester), at-risk genotypes, and indices
of growth and neurodevelopment.
Cost
:$748,512.00
Research Component
:Health Effects
Project IDs:
ID Code
:R830827
Project type
:EPA Grant