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RAT STRAIN AND STOCK COMPARISONS USING A FUNCTIONAL OBSERVATIONAL BATTERY: BASELINE VALUES AND EFFECTS OF AMITRAZ
Citation:
Moser, V., K. McDaniel, AND P. Phillips. RAT STRAIN AND STOCK COMPARISONS USING A FUNCTIONAL OBSERVATIONAL BATTERY: BASELINE VALUES AND EFFECTS OF AMITRAZ. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/091 (NTIS PB91200253), 1991.
Description:
A functional observational battery (FOB) was utilized to assess the effects of 3-day exposure to the formamidine pesticide amitraz in outbred Sprague-Dawley derived and inbred Fischer-344 derived (F344) rats (both from Charles River Laboratories), and in outbred Long-Evans rats obtained from two commercial suppliers (Charles River Breeding Laboratories and Blue Spruce Farms). ignificant strain and stock differences were obtained in baseline values for one-third of the FOB measures. n most cases, F344 rats were different from the others. haracteristic signs of amitraz exposure consist ink of increased excitability, hyperreactivity, and physiological and autonomic change were evident in all treated rats. hese effects increased with repeated dosing, and many were still present 6 days after dosing. n individual measures, there were differences between the strains and stocks in terms of sensitivity and time course of amitraz effects. n general, Blue Spruce Long-Evans rats displayed more effects of amitraz and F344 rats recovered more quickly than others. n the other hand, Sprague-Dawley rats showed the largest increases in the sensorimotor responses to stimuli. These data indicate that although some behavioral and physiological parameters showed strain and vendor differences, both in baseline values and the effects of amitraz, conclusions concerning its neurotoxic potential in a screening context would be similar.
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RAT STRAIN AND STOCK COMPARISONS USING A FUNCTIONAL OBSERVATIONAL BATTERY: BASELINE VALUES AND EFFECTS OF AMITRAZ