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EFFECTS OF EXPOSURE TO PEROXYACETYL NITRATE ON SUSCEPTIBILITY TO ACUTE AND CHRONIC BACTERIAL INFECTION
Citation:
Thomas, G., J. Fenters, R. Ehrlich, AND D. Gardner. EFFECTS OF EXPOSURE TO PEROXYACETYL NITRATE ON SUSCEPTIBILITY TO ACUTE AND CHRONIC BACTERIAL INFECTION. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-81/603.
Description:
A significant increase in mortality due to acute respiratory pneumonia caused by inhalation of Streptococcus pyogenes aerosol was seen after a single 3-h exposure of mice to 14.8-28.4 mg/cu.m. peroxyacetyl nitrate (PAN). The excess mortality ranged from 8 to 39% and the decrease in survival time from 2.4 to 7.9 d. A single exposure to 25.0 mg/cu.m. PAN resulted in a significant increase in total number of cells lavaged from the lungs but somewhat decreased levels of ATP in alveolar macrophages. PAN did not produce any marked changes in a chronic respiratory infection in mice as measured by Mycobacterium tuberculosis lung titers.