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7,12-DIMETHYLBENZ(A)ANTHRACENE-DEOXYRIBONUCLEOSIDE ADDUCT FORMATION 'IN VIVO': EVIDENCE FOR THE FORMATION AND BINDING OF A MONOHYDROXYMETHYL-DMBA (DIMETHYLBENZ(A)ANTHRACENE) METABOLITE TO RAT LIVER DNA (DEOXYRIBONUCLEIC ACID)
Citation:
Joyce, N. AND F. Daniel. 7,12-DIMETHYLBENZ(A)ANTHRACENE-DEOXYRIBONUCLEOSIDE ADDUCT FORMATION 'IN VIVO': EVIDENCE FOR THE FORMATION AND BINDING OF A MONOHYDROXYMETHYL-DMBA (DIMETHYLBENZ(A)ANTHRACENE) METABOLITE TO RAT LIVER DNA (DEOXYRIBONUCLEIC ACID). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-82/275 (NTIS PB83163477), 1982.
Description:
The polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA) is a potent carcinogen to the female Sprague-Dawley rat, and when administered under conditions that have been shown to produce cancer, results in extensive formation of hydrocarbon-deoxyribonucleoside adducts. Sephadex LH-20 and reverse-phase h.p.l.c. and spectrofluorometric analysis of these adducts demonstrate that at least one adduct results from the binding of 7,12-dimethylbenz(a)anthracene-1,2,3,4-tetrahydro-3,4-dihydroxy-1,2-oxide.