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BIOCHEMICAL, FUNCTIONAL AND MORPHOLOGICAL INDICATORS OF NEUROTOXICITY: EFFECTS OF ACUTE ADMINISTRATION OF TRIMETHYLTIN TO THE DEVELOPING RAT
Citation:
Miller, D. AND J. O'Callaghan. BIOCHEMICAL, FUNCTIONAL AND MORPHOLOGICAL INDICATORS OF NEUROTOXICITY: EFFECTS OF ACUTE ADMINISTRATION OF TRIMETHYLTIN TO THE DEVELOPING RAT. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-84/262 (NTIS PB85193845).
Description:
The neurotoxic organometal, trimethyltin (TMT), was administered to rats on postnatal day (PND)5. Neurotoxicity was assessed throughout subsequent development using morphological, biochemical and functional endpoints. These consisted of brain weight measures and histology (morphology), assays of nervous system-specific proteins (biochemistry) and neurobehavioral indices of activity and learning (function). All three indices were affected.
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BIOCHEMICAL, FUNCTIONAL AND MORPHOLOGICAL INDICATORS OF NEUROTOXICITY: EFFECTS OF ACUTE ADMINISTRATION OF TRIMETHYLTIN TO THE DEVELOPING RATRecord Details:
Record Type:DOCUMENT( REPORT )
Product Published Date:05/24/2002
Record Last Revised:04/16/2004
Record ID:
51378