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CHLORINATED ORGANIC BY-PRODUCTS OF THE REACTION OF N-CHLOROPIPERIDINE WITH STOMACH FLUID FROM LABORATORY ANIMALS
Citation:
Scully, F., K. Mazina, H. Ringhand, AND E. Chess. CHLORINATED ORGANIC BY-PRODUCTS OF THE REACTION OF N-CHLOROPIPERIDINE WITH STOMACH FLUID FROM LABORATORY ANIMALS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-87/230 (NTIS PB87212650), 1987.
Description:
When (36)Cl-N-chloropiperidine (NCP) (300 mg/L as Cl2) was mixed with stomach fluid from laboratory rats (fasted either 24 or 48 hr) and incubated in the dark for 30 min at 37 deg C and at higher pH values, approximately one-third was reduced to chloride and between 7% and 63% of the radiolabel was found to chromatograph in a manner distinctly different from (36)Cl-chloride or (36)Cl-NCP. This new fraction is referred to as the (36)Cl-chloroorganic fraction. The remainder of the radiolabel was associated with (36)Cl-NCP.