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FETOTOXIC EFFECTS OF NICKEL IN DRINKING WATER IN MICE
Citation:
Berman, E. AND B. Rehnberg. FETOTOXIC EFFECTS OF NICKEL IN DRINKING WATER IN MICE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-83/007 (NTIS PB83225383), 1983.
Description:
Nickel chloride was administered in drinking water to pregnant mice from the 2nd through the 17th day of gestation at nickel doses of 0, 500, or 1000 ppm. Fetal or maternal toxicity was not seen after administration of 500 ppm of nickel. However, the higher dose caused spontaneous abortions, loss of fetal mass in survivors, and loss of maternal mass. The oral route of administration via drinking water was at least 2.7 times less effective than parenteral routes in producing fetal effects.
Record Details:
Record Type:DOCUMENT( REPORT )
Product Published Date:06/30/1983
Record Last Revised:12/22/2005
Record ID:
50875