Citation:

Hughes, M., S. Shrivastave, M. Sumler, B. Edwards, J. Goodwin, P. Shah, H. Fisher, AND L. Hall. DERMAL ABSORPTION OF CHEMICALS: EFFECT OF APPLICATION OF CHEMICAL AS A SOLID, AQUEOUS PASTE, SUSPENSION OR IN VOLATILE VEHICLE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/436 (NTIS PB93141356), 1992.

Description:

The purpose of this study was to investigate the dermal absorption of chemicals applied to female F344 rats in different physical forms. hese forms included chemical as a solid, aqueous paste, suspension or dissolved in the volatile vehicle ethanol. he chemicals investigated were radiolabeled 2-sec-butyl-3,5-dinitrophenol (DNBP), 2,4,5- 2',4' ,5'-hexachlorobiphenyl (HCB) and 3,4,3',4',-tetrachlorobiphenyl. he chemicals were applied on the clipped mid-dorsal region of the rat over a 2.54 cm2 area and occluded. rine and feces were collected and assayed for radioactivity. he animals were sacrificed 120 hr post-treatment by exsanguination. adioactivity in the blood, skin (treated and untreated) and carcass was assayed. ermal absorption of DNBP-derived radioactivity was approximately 50% of the recovered dose after application in the four physical forms and the major route of excretion was via the urine. welve percent of th absorbed dose of DNBP was retained in the body at 120 hr. ermal penetration of NCB- derived radioactivity was 5-8% of the recovered dose after application in the four physical forms and the major route of excretion was via the feces. reater than 90% of the absorbed dose of HCB-derived radioactivity was retained in the body at 120 hr. ermal penetration of HCB-derived radioactivity was 6-8% of the recovered dose in the four physical forms and the major route of excretion was via the feces. pproximately 21% of the absorbed dose was retained in the body at 120 hr. he data indicate that for each chemical studied, dermal absorption occurs equally as well regardless of physical form.

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