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EFFECTS OF THE FUNGICIDE TRIADMEFON ON FIXED-INTERVAL PERFORMANCE: COMPARISON WITH METHYLPHENIDATE, D-AMPHETAMINE AND CHLORPROMAZINE
Citation:
Alien, A. AND R. MacPhail. EFFECTS OF THE FUNGICIDE TRIADMEFON ON FIXED-INTERVAL PERFORMANCE: COMPARISON WITH METHYLPHENIDATE, D-AMPHETAMINE AND CHLORPROMAZINE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/021 (NTIS PB92143932).
Description:
Triadimefon is a fungicide that has recently been shown to increase motor activity and also to increase rates of schedule-controlled responding. hese findings indicate that triadimefon resembles psychomotor stimulants. he present experiment was designed to compare triadimefon to known psychomotor stimulants. our rats were trained to perform under a mult FI 1-min FI 5-min schedule of milk reinforcement. hey then received a series of dosages of triadimefon (10-170 g/kg, i.p.) and of methylphenidate (1-17.3 mg/kg, i.p.) in a counterbalanced order. ertain dosages of triadimefon increased response rates for all rats in the FI 1-min component and in the FI 5-min component. ethylphenidate increased response rates in each component for only two rats. emporal patterns of responding were disrupted more in the El 5-min component than in the FI 1-min component by both triadimefon and methylphenidate. erformances were then evaluated following a series of dosages of d-amphetamine (0.3-3.0 mg/kg i.p.) and chlorpromazine (0.5-2.0 mg/kg i.p.). esponse rates in FI 1-min were increased d-amphetamine for three rats and in FI 5-min for two rats. -Amphetamine, like triadimefon and methylphenidate. produced a greater disruption of response patterning in FI 5-min than in FI 1-min. hlorpromazine only decreased response rates, but also produced some disruption in FI 5-min response patterning. hese results extend earlier findings and further support the conclusion that triadimefon shares behavioral properties with psychomotor stimulants.