You are here:
ESTIMATION OF OCTANOL/WATER PARTITION COEFFICIENTS FOR ORGANIC POLLUTANTS USING REVERSE-PHASE HPLC
Citation:
McDuffie, B. ESTIMATION OF OCTANOL/WATER PARTITION COEFFICIENTS FOR ORGANIC POLLUTANTS USING REVERSE-PHASE HPLC. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-81/286 (NTIS PB81230872), 1981.
Description:
Octanol/water partition coefficients (K(ow's)) of organic solutes are estimated with reasonable accuracy (standard deviation + or - 0.25 log K(ow)units) by elution from a C-18 column with 75:25 (v/v) MeOH-H20, based on results with 37 test compounds. Changes in solute activity coefficients from water to 75% MeOH account for the slope of the log K(ow)-log k' plot, where k' is the HPLC capacity factor. The method is used to estimate K(ow)'s for 25 additional organic compounds, and some disparities between the results and those calculated using group addivity-constitutive factors are noted.