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UTILIZATION OF THE RABBIT ALVEOLAR MACROPHAGE AND CHINESE HAMSTER OVARY CELL FOR EVALUATION OF THE TOXICITY OF PARTICULATE MATERIALS. II. PARTICLES FROM COAL-RELATED PROCESSES
Citation:
Garrett, N., J. Campbell, H. Stack, M. Waters, AND J. Lewtas. UTILIZATION OF THE RABBIT ALVEOLAR MACROPHAGE AND CHINESE HAMSTER OVARY CELL FOR EVALUATION OF THE TOXICITY OF PARTICULATE MATERIALS. II. PARTICLES FROM COAL-RELATED PROCESSES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-81/097 (NTIS PB83209833), 1981.
Description:
Rabbit alveolar macrophage (RAM) and Chinese hamster ovary (CHO) cells were used in vitro tests to evaluate the toxicity of particulate effluents from coal gasification, fluidized-bed combustion, and conventional coal combustion. Evaluation of the cytotoxicity of nine samples from coal energy-related processes showed that the sensitivity of the RAM assay was improved substantially when the test was conducted in serum-free media. A linear relationship was observed between percentage cell viability and ATP level in the particle-treated cultures.