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IPCS COLLABORATIVE STUDY ON THE UTILITY OF PLANT TEST SYSTEMS IN GENETIC TOXICOLOGY: ARABIDOPSIS ASSAY FOR MUTAGENICITY
Citation:
Gichner, T., S. Badayev, S. Demchenko, J. Relichova, S. Sandhu, P. Usmonov, O. Usmanova, AND J. Veleminsky. IPCS COLLABORATIVE STUDY ON THE UTILITY OF PLANT TEST SYSTEMS IN GENETIC TOXICOLOGY: ARABIDOPSIS ASSAY FOR MUTAGENICITY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/523 (NTIS PB95148854).
Description:
Four laboratories, two in Czechoslovakia (Brno and Prague) and two in USSR (Moscow and Duschanbe), participated in the International Program On Chemical Safety's (IPCS) Collaborative Study to evaluate the utility of the most commonly used plant test systems, including the Arabidopsis thaliana assay, for assessing the mutagenic potential of environmental agents. ut of the five compounds evaluated in the Arabidopsis assay, 3 compounds; i.e., ethyl methanesulphonate, N-methyl-N-nitrosourea, and 3-azidoglycerol, were reported by all four participating laboratories to be mutagenic. odium azide (NaN3) demonstrated negative response in all tour laboratories; whereas, maleic hydrazide was reported to be weakly mutagenic by one laboratory and no mutagenic response by the other three laboratories.
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IPCS COLLABORATIVE STUDY ON THE UTILITY OF PLANT TEST SYSTEMS IN GENETIC TOXICOLOGY: ARABIDOPSIS ASSAY FOR MUTAGENICITY