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COLCHICINE INHIBITS ELEVATIONS IN BOTH ALVEOLAR-CAPILLARY MEMBRANE PERMEABILITY AND LAVAGE SURFACTANT AFTER EXPOSURE OF THE RAT TO PHOSGENE
Citation:
Ghio, A. AND G. Hatch. COLCHICINE INHIBITS ELEVATIONS IN BOTH ALVEOLAR-CAPILLARY MEMBRANE PERMEABILITY AND LAVAGE SURFACTANT AFTER EXPOSURE OF THE RAT TO PHOSGENE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/333 (NTIS PB94196987).
Description:
This paper addresses the pulmonary toxicity of an Air Toxics pollutant, phosgene (COCl2). our biomarkers of injury were compared following low levels of phosgene inhalation and a pharmacological agent, colchicine, was used to probe the mechanism of phosgene effects. revious paper demonstrated the efficacy of colchicine inhibiting phosgene injury and death. his paper further confirms this protective effect of colchicine and shows that several biomarkers of injury, including accumulation of inflammatory cells into the lung, increased permeability of the air-blood barrier, and synthesis of alveolar surfactant, were all inhibited by colchicine. his finding has scientific significance in that it demonstrates a common cellular mechanism that responds to injury, leading to the need for further investigation of this mechanism. t is potentially of therapeutic significance as well, since colchicine could probably be used to reduce the adverse effects of life-threatening concentrations of pulmonary toxicant gases, such as occur in chemical spills.
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COLCHICINE INHIBITS ELEVATIONS IN BOTH ALVEOLAR-CAPILLARY MEMBRANE PERMEABILITY AND LAVAGE SURFACTANT AFTER EXPOSURE OF THE RAT TO PHOSGENE