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WITHIN-SESSION CHANGES IN PEAK N160 AMPLITUDE OF FLASH EVOKED POTENTIALS IN RATS
Citation:
Herr, D., D. King, V. Griffin, W. Watkinson, W. Ali, AND R. Dyer. WITHIN-SESSION CHANGES IN PEAK N160 AMPLITUDE OF FLASH EVOKED POTENTIALS IN RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/202 (NTIS PB94163813).
Description:
The negative peak occurring approximately 160 msec after stimulation (peak N 160) flash evoked potentials (FEPS) of rats changes with repeated testing. abituation, sensitization, and arousal have all been invoked to explain these changes, but few studies have directly tested these explanations. e examined within-session changes in peak N 160 amplitude with repeated testing, and the modulatory effects of stimulus intensity, and auditory white noise Peak N 160 amplitude increased with daily resting (between-session changes) in an stimulus intensity related manner. n contrast, peak N 160 amplitude underwent within-session increases on early days, and within-session 16 decreases on later days. he within-session-changes were not affected by the stimulus intensity. n rats previously tested in a quiet environment, exposure to acoustic white noise increased motor activity and transiently decreased pe "160 amplitude, which then increased and subsequently decreased with confirmed photic and acoustic stimulation. epeated testing in the presence of noise did not alter the within session changes in peak N 106 amplitude. eart rate showed both within and between session decreases, but was unaffected by noise. he data suggest that the within session changes in peak N160-amplitude may reflect a habituation-like response to the test environment.