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COMPATIBILITY OF ORGANIC SOLVENTS WITH THE MICROSCREEN PROPHAGE-INDUCTION ASSAY: SOLVENT-MUTAGEN INTERACTIONS
Citation:
DeMarini, D.M., B. Lawrence, H. Brooks, AND V. Houk. COMPATIBILITY OF ORGANIC SOLVENTS WITH THE MICROSCREEN PROPHAGE-INDUCTION ASSAY: SOLVENT-MUTAGEN INTERACTIONS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/164 (NTIS PB91231324).
Description:
The following solvents did not induce prophage lambda in the Escherichia coli WP2 s (Microscreen assay: cetone, benzene, chloroform, ethanol, n-hexane, isopropanol methanol, toluene, and a mixture of the three isomers of xylene. imethyl sulfoxide was genotoxic in the presence and absence of 59, and methylene chloride was weakly genotoxic in the presence of 59. he genotoxic potencies of 2-aminoanthracene and 2-nitrofluorene were reduced when dissolved in DMSO or methanol compared to their potencies when dissolved in acetone.