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HYPOTHERMIC EFFECTS OF A HOMOLOGOUS SERIES OF SHORT-CHAIN ALCOHOLS IN RATS
Citation:
Mohler, F. AND C. Gordon. HYPOTHERMIC EFFECTS OF A HOMOLOGOUS SERIES OF SHORT-CHAIN ALCOHOLS IN RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/044 (NTIS PB91191510).
Description:
The purpose of this study was to assess the toxicity of various short-chain alcohols using the thermoregulatory system of the rat as an endpoint. ale Fischer rats developed significant hypothermia following acute administration (i.p.) of methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, or 2-butanol. The hypothermic responses to the six alcohols all showed similar bimodal responses characterized by a threshold dose below which no change in body temperature occurred, and a suprathreshold regression with increasing dose causing greater hypothermia Relative efficacy of the alcohols was compared using both the threshold dose to cause hypothermia and the dose which would cause body temperature to decrease by l degree C. oth measures gave the progression of toxicity from least to most potent of: methanol