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COMPENSATORY CHANGES IN THE HIPPOCAMPUS FOLLOWING INTRADENTATE INFUSION OF COLCHICINE
Citation:
Tilson, H., P. Tandon, S. Barone, Jr., AND W. Mundy. COMPENSATORY CHANGES IN THE HIPPOCAMPUS FOLLOWING INTRADENTATE INFUSION OF COLCHICINE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/025.
Description:
Direct infusion of colchicine into the dentate gyrus of the hippocampus kills granule cells and elicits compensatory behavioral, neurochemical and neuroanatomical changes. olchicine-treated rats are less sensitive to the behavioral effects of cholinergic muscarinic receptor antagonists and more sensitive to cholinergic agonists. hese behavioral changes are associated with time- and dose-dependent alterations in the cholinergic signal transduction mechanism. arbachol-stimulated turnover of phosphoinositides is increased in the hippocampus of colchicine-treated rats; similar changes are not observed in the cortex or striatum of colchicine-treated animals. ntradentate colchicine produces a significant increase in choline acetyltransferase activity and staining for acetylcholinesterase in the hippocampus, suggesting reactive synaptogenesis of cholinergic fibers. ther studies have shown that the integrity of the septohippocampal pathway is necessary for these colchicine-induced compensatory changes to occur. work is in progress to determine the possible alteration of colchicine on G-protein mediated events in the phosphoinositide pathway.