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EXAMINATION OF THE PROCONVULSANT ACTIONS OF PYRETHROID INSECTICIDES USING PTZ AND KINDLING SEIZURE MODELS
Citation:
Gilbert, M., C. Mack, AND S. Acheson. EXAMINATION OF THE PROCONVULSANT ACTIONS OF PYRETHROID INSECTICIDES USING PTZ AND KINDLING SEIZURE MODELS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/281.
Description:
Properties of two pyrethroids was assessed using acute i.p. pentylenetetrazol (PTZ) administration and electrical kindling of the amygdale. he Type I pyrethroid, cismethrin (15 mg/kg, po), produced a 17% reduction in the threshold dosage of PTZ required to induce a seizure, while delaying the onset of clonic seizure activity. o alteration in the duration of clonus or the number of clonic seizure bouts was noted. eltamethrin (10 mg/kg, po), a Type II pyrethroid failed to alter threshold or latency to onset of clonus, but did increase the duration and the number of clonic seizure bouts. cismethrin (8 or 15 mg/kg) and deltamethrin (6 or 10 mg/kg), were administered daily, 2 hours prior to electrical kindling stimulation. oth pyrethroids facilitated amygdale kindling to a similar degree, but only at dosages that also evoked strong signs of behavioral toxicity (10 mg/kg and 15 mg/kg, po, for deltamethrin and cismethrin, respectively). eltamethrin, however, induced spontaneous seizures in partially kindled animals in the absence of stimulation. t was concluded that pyrethroids may possess some proconvulant properties at high dosages. esults are interpreted in view of the actions of pyrethroids on sodium channel kinetics.