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GENOTOXIC ACTIVITY OF ORGANIC CHEMICALS IN DRINKING WATER
Citation:
Meier, J. GENOTOXIC ACTIVITY OF ORGANIC CHEMICALS IN DRINKING WATER. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-88/309 (NTIS PB89202428).
Description:
The information summarized in this review provides substantial evidence for the widespread presence of genotoxins in drinking water. In many, if not most cases, the genotoxic activity can be directly attributed to the chlorination stage of drinking water treatment. The genotoxic activity appears to originate primarily from reactions of chlorine with humic substances in the source waters. Genotoxic activity in drinking water concentrates has been most frequently demonstrated using bacterial mutagenicity tests but results with mammalian cell assay systems are generally consistent with the findings from the bacterial assays. There is currently no evidence for genotoxic damage following in vivo exposures to animals. n some locations genotoxic contaminants of probable industrial and/or agricultural origin occur in the source waters and contribute substantially to the genotoxic activity of finished drinking waters. The method used for sample concentration can have an important bearing on study results. In particular, organic acids account for most of the mutagenicity of chlorinated drinking water, and their recovery from water requires an acidification step prior to extraction or XAD resin adsorption. ecently, one class of acidic compounds, the chlorinated hydroxyfuranones, has been shown to be responsible for a major part of the mutagenic activity.Strategies that have been employed to reduce genotoxins in drinking water include granular activated carbon (GAC) filtration, chemical destruction, and alternative means of disinfection (i.e., ozone, chlorine dioxide, and monochloramine). AC treatment has been found to be effective for removal of mutagens from drinking water even after the GAC is beyond its normal use for organic carbon removal. ll disinfectant chemicals appear to have the capacity of reacting with organic mat ter in the source water during water treatment to produce mutagenic activity. owever, the levels of mutagenicity formed with the alternative disinfectants have been generally less than those seen with chlorine and, especially in the case of ozone, highly dependent on the source water. Overall, the positive results from in vitro genotoxicity studies, the limited evidence from carcinogenicity studies in experimental animals, the demonstration of genotoxic and carcinogenic activity for a number of identified chlorination by-products, and the results of several human epidemiologic studies taken together suggest that exposure to chlorination by-products in drinking water should be minimized. The question of how best to accomplish this while maintaining a microbiologically safe drinking water needs to be resolved.