You are here:
CARBOXYHEMOGLOBIN AND BRAIN BLOOD FLOW IN HUMANS
Citation:
Benignus, V., M. Petrovick, L. Newlin-Clapp, AND J. Prah. CARBOXYHEMOGLOBIN AND BRAIN BLOOD FLOW IN HUMANS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/314 (NTIS PB92227552).
Description:
It has been shown that with increased carboxyhemoglobin (COHb) and associated decrease in blood oxygen-carrying capacity, a compensatory increase in brain-blood flow (BBF) develops. he BBF response in humans has been shown to be quite variable. wo experiments were conducted in which humans were exposed to sufficient carbon monoxide (CO) to produce COIL levels up to 184/do BBF was measured by the method of impedance plethysmography. he first was a pilot study in which BBF in 14 men was studied after transient exposure to various concentrations of CO in air. BF increased as a function of COHb, but not to the same extent (or at all) in some subjects. n a confirmatory experiment with 12 men, DBF was measured once per hr during a four-hr experiment. ll 12 subjects received CO. he variation of the BBF response among subjects was large and statistically significant while the variation over time was not significant. hus it appears that the magnitude of the BBF response is unique for a given subject and differs across subjects. hese results may help predict CO-induced behavioral decrements in future studies if subjects whose BBF response to COHb is small or absent are also more susceptible to impairment by acute CO exposure.