You are here:
PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELING
Citation:
Andersen, M. PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELING. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/319 (NTIS PB94197175).
Description:
Physiologically-based pharmacokinetic (PB-PK) models attempt to provide both a realistic anatomic description of the animal to which a drug or toxic chemical has been administered and a biologically accurate representation of the physiological pathways for chemical storage, metabolism and elimination in the animal, Because these models explicitly incorporate information about the biological factors which affect chemical disposition, they are particularly useful for high-to-low dose and interspecies extrapolation of pharmacokinetics. he complexity of any particular PB-PK model depends on the chemical studied and the objectives underlying model development. he primary focus of this brief overview is on the structure of PB-PK models developed for three specific classes of chemicals: olatile organic compounds (VOCs), dioxin-like chlorinated aromatic hydrocarbons, and retinoids. n addition, the risk assessment objectives underpinning model development and the continuing data needs in refining and extending these models are briefly discussed.