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ULTRASTRUCTURE OF NORMAL AND NEOPLASTIC EXOCRINE PANCREAS IN THE MUMMICHOG, FUNDULUS HETEROLCLITUS
Citation:
Vogelbein, W. AND J. Fournie. ULTRASTRUCTURE OF NORMAL AND NEOPLASTIC EXOCRINE PANCREAS IN THE MUMMICHOG, FUNDULUS HETEROLCLITUS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/168.
Description:
The ultrastructure of normal exocrine pancreas and exocrine pancreatic neoplasms in Fundulus heteroclitus from a creosote-contaminated environment in the Elizabeth River, Virginia, is described. he normal exocrine pancreas in this species was an anastomosing tubular rather than a compound tubuloacinar gland, with secretory parenchymal cells organized as branched, anastomosing tubules around a central ductular system. he pancreatic ductular system consisted sequentially of rare terminal canalicular lumens lined exclusively by acinar cells, pancreatic preductules lined by an acinar and centroductular cell, pancreatic ductules lined by epithelial cells resembling the centroductular cell, and larger pancreatic ducts, lined with cuboidal or columnar biliary epithelium and surrounded by basal lamina and stroma. cinar cell adenomas were well-differentiated and retained their tubular organization and relationship between acinar and centroductular cell. ome adenomas exhibited necrosis and cellular degeneration. cinar cell carcinomas ranged from well to poorly differentiated, exhibiting loss of cell polarity, moderate to severe nuclear pleomorphism, great variation in size, shape, and number of zymogen granules, variability in RER content, and cellular degeneration including mitochondrial swelling and formation of autophagic vacuoles.