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TERATOLOGIC EFFECTS OF LONG-TERM EXPOSURE TO DIESEL EXHAUST EMISSIONS (RATS)
Citation:
Werchowski, K., V. Chaffee, AND G. Briggs. TERATOLOGIC EFFECTS OF LONG-TERM EXPOSURE TO DIESEL EXHAUST EMISSIONS (RATS). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-80/010.
Description:
This research project was initiated with the objective of evaluating the potential for diesel exhaust emissions to produce malformations in rat fetuses. The dams were exposed by the inhalation route to a 10% concentration of diesel exhaust emissions in inhalation chambers on days 6 through 15 of gestation. Methods used conform to the guideline developed by the Food and Drug Administration for evaluating teratogenic effects in rats. The results of the exposure of pregnant rats indicate that diesel exhaust emissions have no effect upon normal development of rat fetuses. Diesel exhaust emissions did not effect any of the parameters evaluated to assess maternal toxicity nor total number of fetuses born.