You are here:
MATHEMATICAL MODEL FOR THE SELECTIVE DEPOSITION OF INHALED PHARMACEUTICALS
Citation:
Martonen, T. MATHEMATICAL MODEL FOR THE SELECTIVE DEPOSITION OF INHALED PHARMACEUTICALS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/033.
Description:
To accurately assess the potential therapeutic effects of airborne drugs, the deposition sites of inhaled particles must be known. erein, an original theory is presented for physiologically based pharmacokinetic modeling and related prophylaxis of airway diseases. he mathematical model describes the behavior and fate of particles in the lungs of adult human subjects under various breathing conditions. he related computer code is designed to calculate total and ompartmental (tracheobronchial (TB) and pulmonary (P)) distributions of inhaled aerosols. n this manuscript, the model is first validated via comparisons of predicted deposition patterns with laboratory data from human inhalation exposure experiments; then,.it is applied to determine which factors most influence the dosimetry of inhaled particles. n this format, deposition patterns are explicitly related to: particle characteristics; ventilatory parameters; and, intersubject variabilities of lung morphologies. he dosimetric model was developed to improve the efficacy of erosol therapy via the selective deposition of inhaled pharmaceuticals at prescribed lunglocations to elicit optimum effects.