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COGNITIVE AND NEUROANATOMICAL EFFECTS OF TRIETHYLTIN IN DEVELOPING RATS: ROLE OF AGE OF EXPOSURE
Citation:
Freeman, Jr., J., S. Barone, Jr., AND a. Stanton. COGNITIVE AND NEUROANATOMICAL EFFECTS OF TRIETHYLTIN IN DEVELOPING RATS: ROLE OF AGE OF EXPOSURE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/321 (NTIS PB94197159), 1994.
Description:
Long-Evans rat pups were injected i.p. on Postnatal Day 5 (PND5) or 12 with 0, 3, or 5 mg/kg triethyltin sulfate (TET) and then tested on T-maze delayed alternation (DA) on PND21 or 28. A learning was impaired on PND21 and 28 in pups given 5 mg/kg TET. ups given 5 mg/kg TET on PND 5 were more impaired on DA than pups given 5 mg/kg TET on PND12. ups given 3 mg/kg TET on PND5 or 12 were unimpaired on DA at either age of testing. n the day following DA training, pups were sacrificed for histological assessment employing Nissl-staining or immunohistochemical staining for glial fibrillary acidic protein (GFAP), a putative marker of gliosis. ups given 5 mg/kg TET on PND5 showed increases in GFAP immunoreactivity (IR) in subiculum, amygdala, hippocampus, piriform cortex, and entorhinal cortex with concomitant decreases in Nissl-stained cells in these regions. ups given 5 mg/kg TET on PND12 showed increases in GFAP IR in piriform cortex, amygdala and dorsal hippocampus with concomitant decreases in Nissl-stained cells in these regions. xposure to 3 mg/kg TET on PND5 and PND12 produced a mild increase in GFAP IR in piriform cortex and amygdala but no discernible loss.