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PRIORITIES FOR BIOLOGIC MARKERS RESEARCH IN ENVIRONMENTAL HEALTH
Citation:
Fowle, J. AND K. Sexton. PRIORITIES FOR BIOLOGIC MARKERS RESEARCH IN ENVIRONMENTAL HEALTH. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/123 (NTIS PB93181113), 1992.
Description:
Recent advances in molecular and cellular biology allow for measurement of biologic events or substances that may provide markers of exposure, effect or susceptibility in humans. he application of these new and emerging techniques to environmental health offers the possibility of significantly reducing the uncertainties that traditionally hamper risk assessments. he EPA health research program places a high priority on the validation of appropriate biologic markers and their application to high priority Agency issues. he rationale for EPA's biomarker research program is presented and future research directions are discussed. xposure biomarkers will receive most of the research emphasis in the near term, particularly body burden indicators of exposures to high priority chemicals, such as benzene, ozone, selected heavy metals, and organophosphate pesticides. esearch on effects biomarkers will attempt to validate the relationship between the observed biological effects and adverse health consequences in humans, especially for cancer, pulmonary toxicity, neurotoxicity, and reproductive/ developmental toxicity.