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AGE-RELATED ALTERATIONS IN THE STIMULATED RELEASE IN VITRO OF CATECHOLAMINES AND LUTEINIZING HORMONE-RELEASING HORMONE FROM THE MALE RAT HYPOTHALAMUS
Citation:
Goldman, J., R. Cooper, G. Rehnberg, S. Gabel, AND W. McElroy. AGE-RELATED ALTERATIONS IN THE STIMULATED RELEASE IN VITRO OF CATECHOLAMINES AND LUTEINIZING HORMONE-RELEASING HORMONE FROM THE MALE RAT HYPOTHALAMUS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-87/128 (NTIS PB88144423), 1987.
Description:
Using an in vitro perifusion system, the present study investigated the possibility that alterations in catecholamine and luteinizing hormone-releasing hormone (LHRH) secretion from the male rat mediobasal hypothalamus are present during the period of middle-age. The results indicate that, while tissue concentrations and baseline secretion of norepinephrine, dopamine and LHRH were similar between age groups, the patterns of dopamine and LHRH release in response to a series of depolarizing stimuli was different in the older animals. After all challenges, dopamine concentrations in the perifusate declined much more sharply for the middle-aged group, a finding that may be associated with a decrease with age in the pool of transmitter available for ready release. (Copyright (c) 1987 Plenum Publishing Corporation.)