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ANTAGONISM OF CHLOROBENZENE-INDUCED HEPATOTOXICITY BY LINDANE
Citation:
Chadwick, R., T. Scotti, M. Copeland, M. Mole, AND R. Froehlich. ANTAGONISM OF CHLOROBENZENE-INDUCED HEPATOTOXICITY BY LINDANE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-84/032 (NTIS PB84206119), 1984.
Description:
In a 2x2 factorial designed experiment involving chlorobenzene and gamma-hexachlorocyclohexane (lindane), the hepatotoxicity induced by a challenge dose of chlorobenzene was altered by the pretreatments due to selective changes in various metabolic pathways. These changes resulted in either (1) a marginally significant decrease in hepatotoxicity (chlorobenzene-pretreatment); (2) significant reduction in both the incidence and severity of the lesions (lindane-pretreatment); or (3) absence of centrilobular hepatocellular necrosis in all but 1 of 12 rats where a minimal degree of necrosis was present (chlorobenzene + lindane-pretreatment).