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METABOLIC INTERACTIONS OF HORMONAL STEROIDS AND CHLORINATED HYDROCARBONS: EFFECTS OF NEONATAL TREATMENT WITH O,P'-DDT ON THE DEVELOPMENT OF THE STEROIDOGENIC ENDOCRINE SYSTEM OF THE MALE RAT
Citation:
Campbell, K. METABOLIC INTERACTIONS OF HORMONAL STEROIDS AND CHLORINATED HYDROCARBONS: EFFECTS OF NEONATAL TREATMENT WITH O,P'-DDT ON THE DEVELOPMENT OF THE STEROIDOGENIC ENDOCRINE SYSTEM OF THE MALE RAT. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-77/042 (NTIS PB272669), 1977.
Description:
The study generated approaches to the measurements of the potential of xenobiotics to alter reproductive capacity and viability which may allow improvement of those currently in use. More specifically, it identified the effects of neonatal exposure to the model compound, o,p'-DDT (1,1,-trichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)-ethane), on the developing steroidogenic endocrine system of the model animal, the male rat. The effect of exposures by direct injections before day 5 of age and by indirect treatment via an o,p'-DDT injected dam were examined initially by measurement of growth, organ weights, organ histology, and of serum corticosterone and luteinizing hormone (LH). Later experiments included determinations of the effects of o,p'-DDT on the serum LH responses to challenges of the hypothalamo-pituitary axis with adult castration and repeated injections of luteinizing hormone releasing hormone (LHRH). The results are discussed in relation to previous work on steroids and o,p'-DDT in several animal systems, to possible mechanisms, to prospective experiments and to the original goal of the research.