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DNA ADDUCT PROFILES AND LEVELS IN PLACENTA, BLOOD AND LUNG IN RELATION TO CIGARETTE SMOKING AND SMOKY COAL EMISSIONS
Citation:
Gallagher, J., J. Mumford, X. Li, T. Shank, D. Manchester, AND J. Lewtas. DNA ADDUCT PROFILES AND LEVELS IN PLACENTA, BLOOD AND LUNG IN RELATION TO CIGARETTE SMOKING AND SMOKY COAL EMISSIONS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/031, 1993.
Description:
Human exposures to benzo(a)pyrene (B(a)P) present in smoky coal emissions are nearly 20-200 times greater than exposure to B(a)P from smoking 1-2 packs of cigarettes per day. e compared DNA adducts resulting from cigarette smoking and smoky coal exposures in blood cells, placental syncytial nuclei, whole placental tissue homogenates and lung cells. NA adduct levels for both white blood cells (WBC) and lymphocyte DNA were approximately 2.5-fold higher in smokers compared to non-smokers (p <0.01). No exposure-related adducts were detected in either WBC DNA, or placental tissue DNA isolated from smoky coal-exposed individuals, despite higher exposure to B(a)P (ug/day) and aromatic organics (mg/day) compared to exposures resulting from smoking. NA adducts were approximately 4 fold higher in (BAL) from smoky oal-exposed individuals compared to unexposed individuals.