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THE METABOLISM OF NALED INHALED BY RATS
Citation:
Berteau, P. AND R. Chiles. THE METABOLISM OF NALED INHALED BY RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-77/033 (NTIS PB271976), 1977.
Description:
Naled (Dibrom) was prepared with a (14)carbon label in the 1-ethyl position. The labeled compound was administered in appropriate formulation vehicles to female rats by the inhalation, oral or intraperitoneal routes. Treated animals were either placed in metabolism cages and their excreta and expiration of radioactivity monitored during 48 hours, or they were quickly dissected after sacrifice, the lungs and stomach extracted with ether and metabolic breakdown products analyzed for (14)C products by thin layer chromatography. Some animals were also used to determine the deposition and early distribution of inhaled naled. Urinary levels of radioactivity were higher when animals inhaled the compound than when it was administered by the other routes. Levels deposited in the lung were very low and this fact limited the generation of analytical data on the metabolic changes. However, no evidence was provided to indicate that there was a preferential metabolism to the debrominated form of naled (dichlorvos) when the compound was inhaled contrasted to other routes of administration.