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REGIONAL PATTERNING OF HORMONES IN THE FEMALE RAT ANTERIOR PITUITARY: DISPROPORTIONATE CHANGES OVER THE ESTROUS CYCLE
Citation:
Goldman, J., R. Cooper, G. Rehnberg, K. Booth, W. McElroy, AND J. Hein. REGIONAL PATTERNING OF HORMONES IN THE FEMALE RAT ANTERIOR PITUITARY: DISPROPORTIONATE CHANGES OVER THE ESTROUS CYCLE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/472 (NTIS PB91115964), 1989.
Description:
The present study addressed the possibility that regional differences exist in the typical patterning of anterlor pituitary hormones seen over the estrous cycle. he results show that LH in the rostral area of the pituitary, significantly higher than in other regions on diestrus, rises markedly on proestrus before falling late on that afternoon to concentrations comparable to other areas. maller cyclic changes were seen for lateral and caudo-central areas. he pattern of regional FSH concentrations on diestrus, while similar to LH, does not show the proestrus fall in the rostral region. rolactin declines from a high on diestrus I to a low on late proestrus, but no regional disparities are present. SH shows distinct regional differences and a fall in concentrations that coincides with the reported rise in serum estradiol. hese findings indicate that the preovulatory surge of LH may represent egionally disproportionate event, possibly involving inequalities in the relative amounts of gonadotropin-releasing hormone reaching various areas of the pituitary or differences in the ability of this releasing hormone to trigger LH release.