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AEROSOL THERAPY IMPLICATIONS OF PARTICLE DEPOSITION PATTERNS IN SIMULATED HUMAN AIRWAYS
Citation:
Martonen, T. AEROSOL THERAPY IMPLICATIONS OF PARTICLE DEPOSITION PATTERNS IN SIMULATED HUMAN AIRWAYS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/056 (NTIS PB91191635), 1991.
Description:
The efficacy of inhalation therapy may be improved by the selective deposition of aerosolized medicines, by explicitly targeting and delivering drugs to prescribed lung sites. ere, the deposition patterns of test aerosols, mapped in surrogate respiratory tracts consisting of replica laryngeal casts and fabricated tracheobronchial models, are analyzed. articles were preferentially deposited at bifurcations, specifically at carinal ridges. vidence from other investigations indicates that mucociliary clearance may be impeded at such sites is when these two effects are coupled, the findings suggest that epithelial cells and receptors at airway branching sites may receive concentrated doses of Inhaled pharmacological agents. o focus the effects of airborne drugs the lung should, therefore, be considered as a serial network of Y-shaped bifurcation units. he findings have important implications to aerosol therapy protocols including: 1) the treatment of bronchogenic carcinomas because malignant tumors have a predilection for upper airway bifurcations; and, (2) lung diseases related to the afferent nervous system since components of neural pathways frequent such locations.