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DISTRIBUTION, COVALENT BINDING, AND DNA ADDUCT FORMATION OF 7,12-DIMETHYLBENZ(A)ANTHRACENE IN SENCAR AND BALB/C MICE FOLLOWING TOPICAL AND ORAL ADMINISTRATION (JOURNAL VERSION)
Citation:
Morse, M., W. Baird, AND G. Carlson. DISTRIBUTION, COVALENT BINDING, AND DNA ADDUCT FORMATION OF 7,12-DIMETHYLBENZ(A)ANTHRACENE IN SENCAR AND BALB/C MICE FOLLOWING TOPICAL AND ORAL ADMINISTRATION (JOURNAL VERSION). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-87/392 (NTIS PB89105902), 1987.
Description:
The distribution and macromolecular binding of 7,12-dimethylbenz(a)anthracene (DMBA) were examined in SENCAR and Balb/c mice to determine if these factors could account for the greater susceptibility in initiation-promotion assays following topical application in comparison to oral administration or the much greater susceptibility of the SENCAR mouse. Both the amount of DMBA in skin and the covalent binding of DMBA to epidermal DNA were greater following topical administration indicating that the known differences in efficiency of epidermal tumor formation could be due to differences in initiation by DMBA. Differences in DMBA distribution and macromolecular binding between SENCAR and Balb/c mice did not provide an explanation for the greater sensitivity of SENCAR mice to DMBA-induced tumorigenesis.