You are here:
ROLE OF HYPERPLASTIC NODULES IN DICHLOROACETIC ACID INDUCED HEPATOCARCINOGENESIS IN B6C3F1 MALE MICE
Citation:
Richmond, R., A.B. DeAngelo, C. Potter, AND F. Daniel. ROLE OF HYPERPLASTIC NODULES IN DICHLOROACETIC ACID INDUCED HEPATOCARCINOGENESIS IN B6C3F1 MALE MICE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/202 (NTIS PB91242610), 1991.
Description:
Dichloroacetic acid (DCA) is a hepatocarcinogen in the male B6C3FI mouse. t induces primarily hyperplastic nodules (HN) prior to the appearance of hepatocellular adenoma (HA) or carcinoma (HC). his study was undertaken to determine the role of HN in the progression of DCA-induced hepatocarcinogenesis. ive tumor markers were assessed: 21 ras, P39 c-jun, phosphotyrosine (PT), aldehyde dehydrogenase (ALD), and a-fetoprotein (AFP). ll were known to be expressed in neoplastic lesions. he results demonstrated: 1) Except for c-jun, HN expressed markers significantly less often than either HA or HC. qual expression of c-jun occurred in any of the 3 lesion types. 2) HN that were marker positive contained small nests of marker positive hepatocytes among a field of normal appearing unstained hepatocytes. o marker-positive cells were detected in normal appearing liver outside of NM. ltered foci were few and did not express these markers. hese results support the idea that the nests within HN are areas of transformed or neoplastic hepatocytes. he absence of marker expression in normal liver and in the AF indicates that HN may be the only significant preneoplastic lesion in DCA-induced carcinogenesis.
URLs/Downloads:
ROLE OF HYPERPLASTIC NODULES IN DICHLOROACETIC ACID INDUCED HEPATOCARCINOGENESIS IN B6C3F1 MALE MICE