You are here:
MULTIPLE-SITE CARCINOGENICITY OF BENZENE IN FISCHER 344 RATS AND B6C3F MICE
Citation:
Huff, J., J. Haseman, G. Boorman, S. Eustis, R. Maronpot, D.M. DeMarini, A. Peters, AND R. Pershing. MULTIPLE-SITE CARCINOGENICITY OF BENZENE IN FISCHER 344 RATS AND B6C3F MICE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/224 (NTIS PB90146069), 1989.
Description:
Two-year toxicology and carcinogenesis studies of benzene were conducted in groups of 50 F344/N rats and 50 B6C3F1 mice of each sex and for each of three exposure doses and vehicle controls. hese studies were conducted because of large production volume and widespread human exposure to benzene, because of the epidemiologic association with leukemia, and because previous studies were considered inadequate for determining carcinogenicity. oses of 0, 50, 100 or 200 mg/kg body weight benzene in corn oil (5 ml/kg) were administered by gavage to male rats, 5 days per week for 103 weeks. Doses of 0, 25, 50, or 100 mg/kg benzene in-corn oil were administered by gavage to female rats and to male and female mice for 103 weeks. t week 92 for rats and week 91 for mice, survival was greater than 60% in all groups; most of the animals that died before week 103 had neoplasia. enzene-associated nonneoplastic or neoplastic effects on the hematopoietic system, Zymbal gland, forestomach, and adrenal gland were found for rats and mice. Further, the oral cavity was affected in rats, and the lung, liver, harderian gland, preputial gland, ovary, and mammary gland were affected in mice. These unequivocal observations show clearly that benzene is a trans-species, trans-sex, multi-site, potent carcinogen.
