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EVALUATION OF THE NEPHROTOXICITY OF COMPLEX MIXTURES CONTAINING ORGANICS AND METALS: ADVANTAGES AND DISADVANTAGES OF THE USE OF REAL-WORLD COMPLEX MIXTURES
Citation:
Simmons, J., R. Yang, AND E. Berman. EVALUATION OF THE NEPHROTOXICITY OF COMPLEX MIXTURES CONTAINING ORGANICS AND METALS: ADVANTAGES AND DISADVANTAGES OF THE USE OF REAL-WORLD COMPLEX MIXTURES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/347, 1995.
Description:
The nephrotoxicity of complex industrial waste mixtures and a chemically-characterized synthetic chemical mixture are described and reviewed, respectively. dult, male F-344 rats were gavaged with samples of complex industrial waste and nephrotoxicity evaluated 24 hr later. of the 10 tested samples, 4 were nephrotoxic, which was not eadily predicted from the chemical characterization data. n approach that avoids some of the difficulties associated ith real-world mixtures is use of a chemically-defined synthetic complex mixture. dult, male F-344 rats received for 14 days a 10% solution (10% MIX) of a 25-chemical mixture, then were gavaged with carbon tetrachloride. ecause 10% MIX decreased feed and water consumption, restricted water and feed controls were included. hile 10% MIX increased relative kidney weight, this appeared to be an indirect effect due to decreased water and feed consumption. hallenge with CC14 had little or no effect on renal parameters. n summary, a variety of experimental approaches will be needed to determine the health risks from exposure to chemical mixtures.