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CHARACTERIZATION OF DOXYLAMINE AND PYRILAMINE METABOLITES VIA THERMOSPRAY/MASS SPECTROMETRY AND TANDEM MASS SPECTROMETRY
Citation:
Korfmacher, W., C. Holder, L. Betowski, AND R. Mitchum. CHARACTERIZATION OF DOXYLAMINE AND PYRILAMINE METABOLITES VIA THERMOSPRAY/MASS SPECTROMETRY AND TANDEM MASS SPECTROMETRY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-88/080 (NTIS PB89103576), 1988.
Description:
Analysis of doxylamine N-oxide and pyrilamine N-oxide as synthetic standards and biologically derived metabolites by thermospray mass spectrometry (TSP/MS) provided (M + H)+ ions for each metabolite. TSP/tandem mass spectrometry (TSP/MS/MS) of the (M + H)+ ions provided fragment ions characteristic of these metabolites. In addition, TSP mass spectrometry and TSP/MS/MS analysis of ring-hydroxylated N-desmethyldoxylamine, N-desmethylopyrilamine and O-dealkylated pyrilamine is also reported. A fragmentation pathway for analysis by MS/MS of pyrilamine and its metabolites is also proposed. The results demonstrated the utility of TSP/MS for biologically derived metabolites of pyrilamine and doxylamine. (Copyright (c) 1988 by John Wiley & Sons Ltd.)