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INVESTIGATION OF THE METABOLISM OF CHLORINATED HYDROCARBONS IN SUBHUMAN SPECIES
Citation:
Smith, C., S. Cragg, G. Wolfe, AND W. Weigel. INVESTIGATION OF THE METABOLISM OF CHLORINATED HYDROCARBONS IN SUBHUMAN SPECIES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-85/001 (NTIS PB85152387), 1985.
Description:
The purpose of this research program was to provide metabolic data on four rather common drinking water contaminants. The compounds were 1,2,4-trichlorobenzene (TCB), bromodichloromethane (BDC), bis(2-chloroisopropyl) ether (BCIE) and bis(2-chloroethyl) ether (BCEE). The compounds, labeled with 14C, were administered orally and sometimes intravenously, to rats and rhesus monkeys. Studies on TCB included excretion and tissue distribution in rats, pharmacokinetic studies in monkeys and subchronic studies in monkeys. Daily oral doses of 174 mg/kg were uniformly fatal to monkeys in less than one month. Activity of liver enzymes was increased. Pharmacokinetics and tissue distribution of BDC was examined in rats and monkeys. The compound was excreted primarily via the lung either unchanged or as CO2. BCIE in monkeys was also excreted via the lung and was very toxic to the eyes and kidneys following multiple 30 mg/kg oral doses. Preliminary studies of BCEE in two rhesus monkeys produced the same signs of periorbital toxicity as BCIE when oral doses of 10 mg/kg were administered.