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7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED MODULATION OF CYTOKINES INVOLVED IN CYTOTOXIC T LYMPHOCYTE INDUCTION
Citation:
House, R., M. Pallardy, G. Burleson, AND J. Dean. 7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED MODULATION OF CYTOKINES INVOLVED IN CYTOTOXIC T LYMPHOCYTE INDUCTION. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-88/482 (NTIS PB90185273), 1990.
Description:
Murine lymphocytes were exposed to the carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA) and several cytokines were measured. Production of interleukin-1 by macrophages, interleukin-2 by EL-4 thymoma, and gamma interferon by activated splenic lymphocytes were not affected by DMBA. owever, interleukin-5 (also known as T cell replacing factor) was significantly suppressed by DMA. loned cytotoxic T lymphocyte activity was inhibited in a dose-dependent manner by DMBA and the suppression was significantly enhanced by addition of beta or gamma interferon. hese results support the hypothesis that, rather than acting as a non-specific inhibitor of lymphocyte proliferation, DMBA-induced suppression of antigen-specific cytolysis is a mechanism directed against highly-specific cellular targets in the immune process.