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INTERLABORATORY COMPARISON OF THERMOSPRAY AND PARTICLE BEAM LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY INTERFACES: EVALUATION OF A CHLORINATED PHENOXY ACID HERBICIDE LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY ANALYSIS METHOD
Citation:
Jones, T.L., L. Betowski, B. Lesnik, T. Chiang, AND J. Teberg. INTERLABORATORY COMPARISON OF THERMOSPRAY AND PARTICLE BEAM LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY INTERFACES: EVALUATION OF A CHLORINATED PHENOXY ACID HERBICIDE LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY ANALYSIS METHOD. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/317 (NTIS PB92124734), 1991.
Description:
Seven laboratories participated in an interlaboratory evaluation of a liquid chromatography/mass spectrometry (LC/MS) method for the analysis of 10 chlorinated phenoxy acid herbicides. The focus of this evaluation was to test the intercomparability of LC/MS data obtained from two types of LC/MS interfaces [i.e., thermospray (TS) and particle beam (PB)]. ight simulated sample extracts were sent to each laboratory for LC/MS analysis. here were statistically significant differences between interfaces in the quantitative data for all analytes except 2-(2,4,5- trichlorophenoxy) propanoic acid (silvex). article beam exhibited a high positive bias and a low relative standard deviation at the highest sample extract concentration range, 500 u/mL, while TS showed a low bias and a low relative standard deviation at the lowest sample extract concentration range, 5 u/mL. nother factor of this study was to look for any performance differences between interfaces of the same type, but differing manufacturers. tatistical difference was observed, between PB interfaces, for 2-(1-methylpropyl)-4,6-dinitrophenol (dinoseb).
