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INFLUENCE OF PHOSGENE INHALATION ON EXTRAPULMONARY EFFECTS IN MICE (JOURNAL VERSION)
Citation:
Illing, J., M. Mole, J. Graham, T. Williams, AND M. Menache. INFLUENCE OF PHOSGENE INHALATION ON EXTRAPULMONARY EFFECTS IN MICE (JOURNAL VERSION). U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-88/252 (NTIS PB89144984), 1988.
Description:
Results were: exposure of mice for 4 hours to phosgene concentrations ranging from 0.1 ppm to 0.5 ppm resulted in a significant increase in pentobarbital-induced sleeping time vs. air-exposed animals. Blood pentobarbital levels were measured following a 4 hr exposure to 0.5 ppm phosgene. Although there were no significant differences in the slopes of the clearance curves for phosgene- and air-exposed animals, the half life of pentobarbital was increased by 35%. In separate studies, cytochrome P-450, body weights and liver weights were determined for mice exposed to 0.5 ppm phosgene or to filtered air for 4 hrs. No differences were observed for any of the measurements. These results suggest that phosgene has extrapulmonary effects without causing direct effects on the cytochrome P-450 levels. (Copyright (c) 1988 Hemisphere Publishing Corp.)