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AEROSOL DEPOSITION AS A FUNCTION OF AIRWAY DISEASE: CYSTIC FIBROSIS
Citation:
Martonen, T., I. Katz, AND W. Cress. AEROSOL DEPOSITION AS A FUNCTION OF AIRWAY DISEASE: CYSTIC FIBROSIS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/355, 1995.
Description:
Progressive lung disease associated with cystic fibrosis (CF) is a continuous interaction of the processes of airway obstruction, infection and inflammation. ecent literature has suggested that the manifestation of CF could compromise the successful administration of pharmacologic drugs used in its treatment. herefore, we have performed computer simulations to address the applicability of inhaled pharmaceuticals for the treatment of CF. e have used a mathematical model specifically designed for easy adaptation into drug delivery protocols. he model has been used successfully to simulate clinical inhalation exposure tests with human subjects and drug trials. he lungs of patients inflicted with CF were described by different morphologies than healthy (control) subjects. eposition patterns were dramatically affected by CF induced change sin airway dimensions. entilatory parameters were also examined to demonstrate their effects upon drug disposition. he study suggests that targeted drug delivery based on a mathematical model may be a valuable technique to be employed in the treatment of CF airway disease.