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CARCINOGENIC RISK OF NONUNIFORM ALPHA PARTICLE IRRADIATION IN THE LUNGS: RADON PROGENY EFFECTS AT BRONCHIAL BIFURCATIONS
Citation:
Hofmann, W., D. Crawford-Brown, M. Menache, AND T. Martonen. CARCINOGENIC RISK OF NONUNIFORM ALPHA PARTICLE IRRADIATION IN THE LUNGS: RADON PROGENY EFFECTS AT BRONCHIAL BIFURCATIONS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/313 (NTIS PB92227545), 1991.
Description:
The combined effect of enhanced deposition and reduced clearance at bronchial bifurcations leads to increased radon progeny doses within branching sites compared to uniformly distributed activity within a given airway generation. ulti-stage carcinogenesis model was used to predict the probability of lung cancer induction at different sites of the bronchial region. or relatively low radon progeny exposures, lung cancer risk is significantly higher in bifurcation zones, particularly at carinal ridges, than along tubular segments. t sufficiently high exposures, however, lung cancer risk is highest in the tubular portions of a generation. his suggests that the common assumption of a uniform dose distribution provides realistic risk estimates for high uranium miner exposures, but may underestimate lung cancer risk at low, environmental exposures. f concomitant exposure to cigarette smoke is factored into our risk analysis in a multiplicative fashion, then the effect related to risk inhomogeneity becomes even more pronounced.