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SUBCHRONIC TOXICITY STUDY OF OZONATED AND OZONATED/CHLORINATED HUMICS IN SPRAGUE-DAWLEY RATS: A MODEL SYSTEM FOR DRINKING WATER DISINFECTION
Citation:
Daniel, F., M. Robinson, H. Ringhand, AND N. Page. SUBCHRONIC TOXICITY STUDY OF OZONATED AND OZONATED/CHLORINATED HUMICS IN SPRAGUE-DAWLEY RATS: A MODEL SYSTEM FOR DRINKING WATER DISINFECTION. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/124 (NTIS PB92164946), 1991.
Description:
Male and female Sprague-Dawley rats were administered drinking water containing humics (1 g/L) alone or after it had been ozonated or ozonated/chlorinated. he rats consumed the treated drinking water ad libitum for a 90-day period. wo levels of humics were studies, 0.25 and 1.0 g/L total organic carbon (TOC). ontrol group received distilled water only. o treatment related effects were observed for body weight gain, organ weights, food and water consumption, and hematological and clinical chemistry parameters. o target organs were identified from the clinical studies or the gross and histopathology. he most significant observation was an increase in liver weights for the male ozonated/chlorinated humics (1 g/L) group. his was not observed in any other group and no biochemical measurements or pathology lesions correlated with the increased liver weights. idney lesions, primarily nephropathy, was a common observation in controls and treated groups with no apparent relationship to humics or the disinfection of humics-containing water. Based on the results of this study, the NOAEL for drinking water containing humics with or without ozonation and chlorination was 1.0 g/L TOC when administered for a 90-day period.