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DIBROMOETHANE EFFECTS ON THE INDUCTION OF GAMMA-GLUTAMYL-TRANSPEPTIDASE POSITIVE FOCI IN RAT LIVER
Citation:
Milks, M., S. Wilt, I. Ali, M. Pereira, AND D. Couri. DIBROMOETHANE EFFECTS ON THE INDUCTION OF GAMMA-GLUTAMYL-TRANSPEPTIDASE POSITIVE FOCI IN RAT LIVER. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-82/272 (NTIS PB83157552), 1982.
Description:
The initiating and promoting activities of 1.2-dibromoethane in rat liver were investigated using the enzyme-altered foci bioassay. The incidence of gamma-glutamyl-transpeptidase (GGT)-positive foci was used as an early histochemical marker for hepatocarcinogenesis. To determine the initiating activity of 1.2-dibromoethane, the halogenated hydrocarbon was administered orally in corn oil as single or multiple doses (60 or 120 mg/kg) either before or after partial hepatectomy. The animals were then given a promoting regimen of 500 ppm phenobarbital in their drinking water. No increase in the incidence of GGT-positive foci was observed in any of the 1.2-dibromoethane initiation groups.