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ABSORPTION OF INHALED REACTIVE GASES
Citation:
Overton, J. AND F. Miller. ABSORPTION OF INHALED REACTIVE GASES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-87/128 (NTIS PB87181434), 1987.
Description:
In inhalation toxicology, an important concept involves the determination of dose as a major component for providing a perspective to judge the applicability of various toxicological results to human exposure conditions. This chapter reviewed some of the biological, physical, and chemical factors that affect dose and that must be understood to interpret experimental toxicological data and to develop theoretical dosimetry models. Dosimetry experiments involving laboratory animals and humans were briefly discussed, showing the variability in uptake according to the reactive gas, animal species, and respiratory tract region. The results of theoretical dosimetry models were illustrated showing the effects on predictions due to different inter- and intraspecies LRT anatomical models, due to different TB liquid lining thicknesses, and due to the chemical rate constant of the liquid lining of the TB region.