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INFLUENCE OF TIME OF EXPOSURE TO CARBON TETRACHLORIDE ON TOXIC LIVER INJURY
Citation:
Bruckner, J., R. Luthra, G. Kyle, S. Muralidhara, AND R. Ramanathan. INFLUENCE OF TIME OF EXPOSURE TO CARBON TETRACHLORIDE ON TOXIC LIVER INJURY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-84/272 (NTIS PB85220424), 1984.
Description:
The study was conducted to determine whether, and by what mechanisms, time of exposure could influence the ability of a model hepatotoxin, carbon tetrachloride (CCl4) to cause liver injury. Rats dosed orally with CCl4 during their active/dark cycle were found to be more susceptible to liver injury than rats dosed during their inactive/light cycle. There was greater hepatic microsomal uptake and metabolism of CCl4 in rats dosed during their active cycle.
Record Details:
Record Type:DOCUMENT( REPORT )
Product Published Date:12/31/1984
Record Last Revised:12/22/2005
Record ID:
46538